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Check rooms and rates
From203US$ /night
Check-in
19Dec2025Select date
Check-out
20Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
-
Close to Mayo Clinic
Perfect
9.0
9.3
/10
4.6
4.5
/5

Rooms with Kitchens

Residence Inn By Marriott Jacksonville-Mayo Clinic Area offers 155 air-conditioned suites, each with a fully equipped kitchen (stovetop, refrigerator, dishwasher), a seating area, and a flat-screen TV with Netflix. Private bathrooms include a hairdryer and free toiletries. Some suites feature a sofa bed and a 50" or 55" SMART HDTV.

Dining Options

Guests can start the day with a buffet or American breakfast. The lobby bar serves healthy food options, specialty cocktails, and smoothies during breakfast hours. A grocery/convenience store on-site provides snacks and essentials.

Leisure & Fitness

The hotel has an outdoor heated pool, a 24-hour fitness center with treadmills, ellipticals, and strength equipment. Guests can relax at the poolside bar or the Claudette O'Brien Gerhold Gallery, a lounge designed for medical guests.

Location & Transport

The hotel is a 2-minute drive from Mayo Clinic Florida and 9 minutes from St Johns Town Center. A complimentary hourly shuttle runs from 7 AM to 5 PM to Mayo Clinic. Northeast Florida Regional Airport is 35 km away.

Services & Accessibility

Services include a 24-hour front desk, free Wi-Fi, a business center, and on-site laundry. Accessible features include roll-in showers, lowered electrical outlets, and van-accessible parking. American In-Home Care offers in-suite nursing services for medical guests.

“Residence Inn's location near the Mayo Clinic makes it a practical choice for medical visits, and the full in-suite kitchens add a layer of convenience for longer stays. I noted the hotel's attention to guest well-being, with features like specialized air quality systems and grocery services. It stands out as a comfortable, service-oriented option in Jacksonville.”
Hotel logo
Grace WhitmanContent & Editorial Director at Familyhotels
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Choose from a variety of room types

Choose from a wide variety of rooms designed for families, including double rooms, family suites, and rooms with breakfast included
One-Bedroom Queen Suite Hearing Accessible
2 persons
52 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
King Studio Suite Sofa Bed Adapted Tub Mobility Accessible
2 persons
38 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
Queen Corner Suite
2 persons
60 m² 
1 King-size bed and 1 Sofa bed
Shower
Coffee machine
King Studio Suite Sofa Bed Hearing Accessible
2 persons
38 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
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Availability and pricing for your selected dates

Book your family’s getaway in a snap with up-to-date availability and pricing!

Facilities

Each family-friendly hotel provides top-notch amenities for an unforgettable stay with your loved ones

General

  • No smoking on site
  • Free Wi-Fi
  • Free parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Lift
  • Fireplace
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Golf course

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Free shuttle service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Grocery shopping service
  • Shops/Commercial services

Dining

  • Bar/ Lounge area
  • Picnic area/ Tables

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots
  • Children's buffet
  • Board games

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Heated swimming pool
  • Outdoor swimming pool
  • Sun loungers
  • BBQ facilities
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Dining table

Bathroom

  • Free toiletries
  • Sink

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Location

4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
Map view
4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
Nearby
Hospital
Mayo Clinic Jacksonville
1.0 km
Restaurants
Bundy Cafe & Atrium
910 m
4500 San Pablo Rd S Mayo Clinic
Explore Jacksonville
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Mayo Clinic Jacksonville
Mayo Clinic Jacksonville
12 minutes walking
World-renowned medical facility known for its patient care, research, and educational programs.
Harbor City Municipal Golf Course
Harbor City Municipal Golf Course
5 minutes' drive
Challenging golf course featuring scenic views, perfect for golfers of all skill levels.
Windsor Parke Golf Club
10 minutes' drive
Beautifully designed, lush fairways, and a relaxed atmosphere make it an ideal golf destination.
Shipwreck Island Water Park
10 minutes' drive
Thrilling water slides and pools provide fun for families and adventure-seekers alike.
Cradle Creek Preserve
Cradle Creek Preserve
45 minutes walking
Quiet nature preserve offering serene walking trails, ideal for relaxation and reflection.
Bundy Cafe & Atrium
Bundy Cafe & Atrium
10 minutes walking
Charming café offering farm-to-table dishes, great coffee, and a cozy atmosphere. Vegetarian options available.
La Nopalera
10 minutes' drive
Authentic Mexican cuisine known for its fresh ingredients and vibrant flavors. Great for family dining.
Regal Beach Boulevard 18
Regal Beach Boulevard 18
10 minutes' drive
Popular movie theater featuring the latest films, perfect for a family outing or a date night.
Mike McCue Park and Boat Ramp
Mike McCue Park and Boat Ramp
10 minutes' drive
Family-friendly park offering boat ramps and picnic areas, ideal for a day of outdoor fun.
Tips on navigating the city
City Centre
Jacksonville35 min  ·  22.7 km
Airports
Jacksonville International Airport (JAX)67 min  ·  44.6 km
St. Augustine, FL (UST)71 min  ·  47.0 km
Train
Jacksonville Electric Authority Southside Generating Station Wharf30 min  ·  19.8 km
Union Station36 min  ·  24.0 km
Get access to exclusive early booking discounts for your family’s upcoming getaway
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
Public parking is possible on site for free.
Internet
is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Pets
Pets are allowed on request.
Number of floors:
7
Number of rooms:
181
Former name
residence inn by marriott jacksonville - mayo clinic area
FAQs
About Residence Inn By Marriott Jacksonville-Mayo Clinic Area
What is the check-in and check-out policy at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Check-in is from 16:00 and check-out is until 11:00.
Is parking available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Public parking is available on-site for free, and no reservation is needed.
What recreational facilities does Residence Inn By Marriott Jacksonville-Mayo Clinic Area offer?
Guests can enjoy an outdoor swimming pool, a 24-hour fitness center, and barbecue facilities.
What are the nearby attractions to Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Mayo Clinic Florida is located just 2 minutes away, while St Johns Town Center is about 9 minutes by car.
What room amenities are provided at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Rooms include air conditioning, a flat-screen TV, a fully equipped kitchen, and a private bathroom with complimentary toiletries.
Does Residence Inn By Marriott Jacksonville-Mayo Clinic Area serve breakfast?
Yes, a buffet or American breakfast is available for guests.
Is there a bar or dining option on-site at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The hotel features an on-site bar and offers food service with healthy options.
What is the pet policy at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Pets are allowed with possible additional charges, and there is a maximum weight limit of 22.7 kg.
What are some key services available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The hotel provides a complimentary shuttle service, a business center, and a 24-hour front desk.
How far is Residence Inn By Marriott Jacksonville-Mayo Clinic Area from Jacksonville International Airport?
The hotel is located 43 km from Jacksonville International Airport.
Are there business facilities available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The hotel features meeting spaces and a business center with complimentary Wi-Fi access.
What languages do staff speak at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Staff are fluent in English and Spanish.

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